Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring

Claire Liu; Jin Tae Kim; Sung Soo Kwak; Aurelie Hourlier-Fargette; Raudel Avila; Jamie Vogl; Andreas Tzavelis; Ha Uk Chung; Jong Yoon Lee; Dong Hyun Kim; Dennis Ryu; Kelsey B. Fields; Joanna L. Ciatti; Shupeng Li; Masahiro Irie; Allison Bradley; Avani Shukla; Jairo Chavez; Emma C. Dunne; Seung Sik Kim; Jungwoo Kim; Jun Bin Park; Han Heul Jo; Joohee Kim; Michael C. Johnson; Jean Won Kwak; Surabhi R. Madhvapathy; Shuai Xu; Casey M. Rand; Lauren E. Marsillio; Sue J. Hong; Yonggang Huang; Debra E. Weese-Mayer; John A. Rogers

doi:10.1002/adhm.202100383

Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring

Claire Liu, Jin Tae Kim, Sung Soo Kwak, Aurelie Hourlier-Fargette, Raudel Avila, Jamie Vogl, Andreas Tzavelis, Ha Uk Chung, Jong Yoon Lee, Dong Hyun Kim, Dennis Ryu, Kelsey B. Fields, Joanna L. Ciatti, Shupeng Li, Masahiro Irie, Allison Bradley, Avani Shukla, Jairo Chavez, Emma C. Dunne, Seung Sik KimJungwoo Kim, Jun Bin Park, Han Heul Jo, Joohee Kim, Michael C. Johnson, Jean Won Kwak, Surabhi R. Madhvapathy, Shuai Xu, Casey M. Rand, Lauren E. Marsillio, Sue J. Hong, Yonggang Huang^*, Debra E. Weese-Mayer^*, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.

Original language	English (US)
Article number	2100383
Journal	Advanced Healthcare Materials
Volume	10
Issue number	17
DOIs	https://doi.org/10.1002/adhm.202100383
State	Published - Sep 8 2021

Funding

C.L., J.‐T.K., S.S.K., and A.H.‐F. contributed equally to this work. D.E.W.‐M., C.M.R., and J.A.R. acknowledge funding support from the Gerber Foundation. C.L. and S.R.M. acknowledge funding support from the National Science Foundation Graduate Research Fellowship Program (NSF DGE‐1842165). This work made use of the Keck‐II facility and the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS‐2025633), the IIN, and Northwestern's MRSEC program (NSF DMR‐1720139). Engineering efforts were supported by the Querrey Simpson Institute for Bioelectronics at Northwestern University. The authors gratefully acknowledge the late Dr. Lauren E. Marsillio for her contributions to this work. The authors also thank all of the patients and their families who participated in this study, as well as the PICU staff of the Ann & Robert H. Lurie Children's Hospital of Chicago.

Keywords

blood pressure
hemodynamics
pediatrics
soft electronics
vital signs monitoring
wireless wearables

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

Access to Document

10.1002/adhm.202100383

Cite this

Liu, C., Kim, J. T., Kwak, S. S., Hourlier-Fargette, A., Avila, R., Vogl, J., Tzavelis, A., Chung, H. U., Lee, J. Y., Kim, D. H., Ryu, D., Fields, K. B., Ciatti, J. L., Li, S., Irie, M., Bradley, A., Shukla, A., Chavez, J., Dunne, E. C., ... Rogers, J. A. (2021). Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring. Advanced Healthcare Materials, 10(17), Article 2100383. https://doi.org/10.1002/adhm.202100383

@article{4378c7be3f004d74bb0b8f90a025f47d,

title = "Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring",

abstract = "Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.",

keywords = "blood pressure, hemodynamics, pediatrics, soft electronics, vital signs monitoring, wireless wearables",

author = "Claire Liu and Kim, {Jin Tae} and Kwak, {Sung Soo} and Aurelie Hourlier-Fargette and Raudel Avila and Jamie Vogl and Andreas Tzavelis and Chung, {Ha Uk} and Lee, {Jong Yoon} and Kim, {Dong Hyun} and Dennis Ryu and Fields, {Kelsey B.} and Ciatti, {Joanna L.} and Shupeng Li and Masahiro Irie and Allison Bradley and Avani Shukla and Jairo Chavez and Dunne, {Emma C.} and Kim, {Seung Sik} and Jungwoo Kim and Park, {Jun Bin} and Jo, {Han Heul} and Joohee Kim and Johnson, {Michael C.} and Kwak, {Jean Won} and Madhvapathy, {Surabhi R.} and Shuai Xu and Rand, {Casey M.} and Marsillio, {Lauren E.} and Hong, {Sue J.} and Yonggang Huang and Weese-Mayer, {Debra E.} and Rogers, {John A.}",

note = "Funding Information: C.L., J.‐T.K., S.S.K., and A.H.‐F. contributed equally to this work. D.E.W.‐M., C.M.R., and J.A.R. acknowledge funding support from the Gerber Foundation. C.L. and S.R.M. acknowledge funding support from the National Science Foundation Graduate Research Fellowship Program (NSF DGE‐1842165). This work made use of the Keck‐II facility and the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS‐2025633), the IIN, and Northwestern's MRSEC program (NSF DMR‐1720139). Engineering efforts were supported by the Querrey Simpson Institute for Bioelectronics at Northwestern University. The authors gratefully acknowledge the late Dr. Lauren E. Marsillio for her contributions to this work. The authors also thank all of the patients and their families who participated in this study, as well as the PICU staff of the Ann & Robert H. Lurie Children's Hospital of Chicago. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",

year = "2021",

month = sep,

day = "8",

doi = "10.1002/adhm.202100383",

language = "English (US)",

volume = "10",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Inc.",

number = "17",

}

Liu, C, Kim, JT, Kwak, SS, Hourlier-Fargette, A, Avila, R, Vogl, J, Tzavelis, A, Chung, HU, Lee, JY, Kim, DH, Ryu, D, Fields, KB, Ciatti, JL, Li, S, Irie, M, Bradley, A, Shukla, A, Chavez, J, Dunne, EC, Kim, SS, Kim, J, Park, JB, Jo, HH, Kim, J, Johnson, MC, Kwak, JW, Madhvapathy, SR, Xu, S, Rand, CM, Marsillio, LE, Hong, SJ, Huang, Y , Weese-Mayer, DE & Rogers, JA 2021, 'Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring', Advanced Healthcare Materials, vol. 10, no. 17, 2100383. https://doi.org/10.1002/adhm.202100383

TY - JOUR

T1 - Wireless, Skin-Interfaced Devices for Pediatric Critical Care

T2 - Application to Continuous, Noninvasive Blood Pressure Monitoring

AU - Liu, Claire

AU - Kim, Jin Tae

AU - Kwak, Sung Soo

AU - Hourlier-Fargette, Aurelie

AU - Avila, Raudel

AU - Vogl, Jamie

AU - Tzavelis, Andreas

AU - Chung, Ha Uk

AU - Lee, Jong Yoon

AU - Kim, Dong Hyun

AU - Ryu, Dennis

AU - Fields, Kelsey B.

AU - Ciatti, Joanna L.

AU - Li, Shupeng

AU - Irie, Masahiro

AU - Bradley, Allison

AU - Shukla, Avani

AU - Chavez, Jairo

AU - Dunne, Emma C.

AU - Kim, Seung Sik

AU - Kim, Jungwoo

AU - Park, Jun Bin

AU - Jo, Han Heul

AU - Kim, Joohee

AU - Johnson, Michael C.

AU - Kwak, Jean Won

AU - Madhvapathy, Surabhi R.

AU - Xu, Shuai

AU - Rand, Casey M.

AU - Marsillio, Lauren E.

AU - Hong, Sue J.

AU - Huang, Yonggang

AU - Weese-Mayer, Debra E.

AU - Rogers, John A.

N1 - Funding Information: C.L., J.‐T.K., S.S.K., and A.H.‐F. contributed equally to this work. D.E.W.‐M., C.M.R., and J.A.R. acknowledge funding support from the Gerber Foundation. C.L. and S.R.M. acknowledge funding support from the National Science Foundation Graduate Research Fellowship Program (NSF DGE‐1842165). This work made use of the Keck‐II facility and the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS‐2025633), the IIN, and Northwestern's MRSEC program (NSF DMR‐1720139). Engineering efforts were supported by the Querrey Simpson Institute for Bioelectronics at Northwestern University. The authors gratefully acknowledge the late Dr. Lauren E. Marsillio for her contributions to this work. The authors also thank all of the patients and their families who participated in this study, as well as the PICU staff of the Ann & Robert H. Lurie Children's Hospital of Chicago. Publisher Copyright: © 2021 Wiley-VCH GmbH

PY - 2021/9/8

Y1 - 2021/9/8

N2 - Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.

AB - Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.

KW - blood pressure

KW - hemodynamics

KW - pediatrics

KW - soft electronics

KW - vital signs monitoring

KW - wireless wearables

UR - http://www.scopus.com/inward/record.url?scp=85105011984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105011984&partnerID=8YFLogxK

U2 - 10.1002/adhm.202100383

DO - 10.1002/adhm.202100383

M3 - Article

C2 - 33938638

AN - SCOPUS:85105011984

SN - 2192-2640

VL - 10

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 17

M1 - 2100383

ER -

Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this