@article{1ee10e1afd4d4e9d840c1700f6d5ad26,
title = "Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health",
abstract = "Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.",
keywords = "biomedical devices, diagnostics, flexible electronics, health monitoring, wireless electronics",
author = "Jaeho Shin and Heling Wang and Kyeongha Kwon and Diana Ostojich and Zach Christiansen and Jaime Berkovich and Yoonseok Park and Zhengwei Li and Geumbee Lee and Rania Nasif and Chung, {Ted S.} and Su, {Chun Ju} and Jaeman Lim and Hitoki Kubota and Akihiko Ikoma and Lu, {Yi An} and Lin, {Derrick H.} and Shuai Xu and Anthony Banks and Chang, {Jan Kai} and Rogers, {John A.}",
note = "Funding Information: J.S., H.W., and K.K. contributed equally to this work. This work was supported by the Querrey–Simpson Institute for Bioelectronics. K.K. acknowledged support by the NRF grant funded by the Korean government (MSIP; Ministry of Science, ICT & Future Planning; No. 2021R1F1A106387111, No. 2022R1C1C1010555, and No. 2020R1A5A8018367). J.S., J.K.C., D.O., Z.C., and J.B. conducted hardware development and data analysis; H.W. developed the FEA models and computational analysis; J.K.C. and K.K. designed the electronics; Y.P., Z.L., R.N., T.S.C., C.J.S., J.L., and Y.A.L. assisted in the device fabrication; G.L. assisted in the characterization; Y.I., A.I., and A.B. assisted in the data analysis; D.H.L. and S.X. conducted the clinical study; J.S. and J.K.C. wrote the manuscript. J.K.C. and J.A.R. supervised the overall research. Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.",
year = "2023",
month = feb,
day = "6",
doi = "10.1002/adhm.202202021",
language = "English (US)",
volume = "12",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "4",
}