Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

J. Liu; A. Lin

doi:10.1038/sj.onc.1210417

Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

J. Liu, A. Lin^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase JNK1 are major players in the cell signaling circuitry, regulating numerous cellular events and being implicated in the process of many human diseases and certain types of cancer. The interplay between NF-κB and JNK1 provides a paradigm that shows how the crosstalk between different signaling pathways decides the function of the cell signaling circuitry. Understanding the wiring of the cell signaling circuitry may hold the key for cell signaling-based therapy of human diseases.

Original language	English (US)
Pages (from-to)	3267-3278
Number of pages	12
Journal	Oncogene
Volume	26
Issue number	22
DOIs	https://doi.org/10.1038/sj.onc.1210417
State	Published - May 14 2007

Funding

This work is partially supported by grants from the National Institutes of Health. We apologize to the authors for not being able to directly cite their work due to the space constraints.

Keywords

Crosstalk
JNK1
NF-κB
Signaling
TNF-α
UV

ASJC Scopus subject areas

Genetics
Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1210417

Cite this

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abstract = "Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase JNK1 are major players in the cell signaling circuitry, regulating numerous cellular events and being implicated in the process of many human diseases and certain types of cancer. The interplay between NF-κB and JNK1 provides a paradigm that shows how the crosstalk between different signaling pathways decides the function of the cell signaling circuitry. Understanding the wiring of the cell signaling circuitry may hold the key for cell signaling-based therapy of human diseases.",

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AB - Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase JNK1 are major players in the cell signaling circuitry, regulating numerous cellular events and being implicated in the process of many human diseases and certain types of cancer. The interplay between NF-κB and JNK1 provides a paradigm that shows how the crosstalk between different signaling pathways decides the function of the cell signaling circuitry. Understanding the wiring of the cell signaling circuitry may hold the key for cell signaling-based therapy of human diseases.

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Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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