Wnt signaling in whole-body regeneration

Christian P. Petersen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Regeneration abilities are widespread among animals and select species can restore any body parts removed by wounds that sever the major body axes. This capability of whole-body regeneration as exemplified in flatworm planarians, Acoels, and Cnidarians involves initial responses to injury, the assessment of wound site polarization, determination of missing tissue and programming of blastema fate, and patterned outgrowth to restore axis content and proportionality. Wnt signaling drives many shared and conserved aspects of the biology of whole-body regeneration in the planarian species Schmidtea mediterranea and Dugesia japonica, in the Acoel Hofstenia miamia, and in Cnidarians Hydra and Nematostella. These overlapping mechanisms suggest whole-body regeneration might be an ancestral property across diverse animal taxa.

Original languageEnglish (US)
Title of host publicationWnt Signaling in Development and Disease
EditorsTerry P. Yamaguchi, Karl Willert
PublisherAcademic Press Inc
Number of pages34
ISBN (Print)9780128201671
StatePublished - Jan 2023

Publication series

NameCurrent Topics in Developmental Biology
ISSN (Print)0070-2153


  • axis formation
  • Evolution
  • Hofstenia
  • Hydra
  • Nematostella
  • Organizer
  • planaria
  • Polarity
  • Positional information
  • Whole-body regeneration
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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