@inbook{e7aa7d45527a45b1b508cbc94963ffed,
title = "Wnt signaling in whole-body regeneration",
abstract = "Regeneration abilities are widespread among animals and select species can restore any body parts removed by wounds that sever the major body axes. This capability of whole-body regeneration as exemplified in flatworm planarians, Acoels, and Cnidarians involves initial responses to injury, the assessment of wound site polarization, determination of missing tissue and programming of blastema fate, and patterned outgrowth to restore axis content and proportionality. Wnt signaling drives many shared and conserved aspects of the biology of whole-body regeneration in the planarian species Schmidtea mediterranea and Dugesia japonica, in the Acoel Hofstenia miamia, and in Cnidarians Hydra and Nematostella. These overlapping mechanisms suggest whole-body regeneration might be an ancestral property across diverse animal taxa.",
keywords = "axis formation, Evolution, Hofstenia, Hydra, Nematostella, Organizer, planaria, Polarity, Positional information, Whole-body regeneration, Wnt",
author = "Petersen, {Christian P.}",
note = "Funding Information: CP thanks members of the Petersen lab for helpful conversations and for funding from the National Institutes of Health, USA (NIGMS R01GM129339 and R01GM130835). Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = jan,
doi = "10.1016/bs.ctdb.2023.01.007",
language = "English (US)",
isbn = "9780128201671",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc",
pages = "347--380",
editor = "Yamaguchi, {Terry P.} and Karl Willert",
booktitle = "Wnt Signaling in Development and Disease",
}