Working memory abilities among children treated for medulloblastoma: Parent report and child performance

Sarah J. Knight; Heather M. Conklin; Shawna L. Palmer; Jane E. Schreiber; Carol L. Armstrong; Dana Wallace; Melanie Bonner; Michelle A. Swain; Karen D. Evankovich; Donald J. Mabbott; Robyn Boyle; Qinlei Huang; Hui Zhang; Vicki A. Anderson; Amar Gajjar

doi:10.1093/jpepsy/jsu009

Working memory abilities among children treated for medulloblastoma: Parent report and child performance

Sarah J. Knight^*, Heather M. Conklin, Shawna L. Palmer, Jane E. Schreiber, Carol L. Armstrong, Dana Wallace, Melanie Bonner, Michelle A. Swain, Karen D. Evankovich, Donald J. Mabbott, Robyn Boyle, Qinlei Huang, Hui Zhang, Vicki A. Anderson, Amar Gajjar

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

ObjectiveWe investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.MethodThis study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.Results There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only. ConclusionsMost children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.

Original language	English (US)
Pages (from-to)	501-511
Number of pages	11
Journal	Journal of pediatric psychology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1093/jpepsy/jsu009
State	Published - Jun 2014

Funding

National Cancer Institute through a Cancer Center Support (CORE) grant (P30-CA21765), the Noyes Brain Tumor Foundation, Musicians Against Childhood Cancer (MACC), and the American Lebanese Syrian Associated Charities (ALSAC).

Keywords

cancer and oncology
cognitive assessment
neurological disorders
neuropsychology

ASJC Scopus subject areas

Developmental and Educational Psychology
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jpepsy/jsu009

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Knight, S. J., Conklin, H. M., Palmer, S. L., Schreiber, J. E., Armstrong, C. L., Wallace, D., Bonner, M., Swain, M. A., Evankovich, K. D., Mabbott, D. J., Boyle, R., Huang, Q., Zhang, H., Anderson, V. A., & Gajjar, A. (2014). Working memory abilities among children treated for medulloblastoma: Parent report and child performance. Journal of pediatric psychology, 39(5), 501-511. https://doi.org/10.1093/jpepsy/jsu009

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title = "Working memory abilities among children treated for medulloblastoma: Parent report and child performance",

abstract = "ObjectiveWe investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.MethodThis study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.Results There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only. ConclusionsMost children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.",

keywords = "cancer and oncology, cognitive assessment, neurological disorders, neuropsychology",

author = "Knight, {Sarah J.} and Conklin, {Heather M.} and Palmer, {Shawna L.} and Schreiber, {Jane E.} and Armstrong, {Carol L.} and Dana Wallace and Melanie Bonner and Swain, {Michelle A.} and Evankovich, {Karen D.} and Mabbott, {Donald J.} and Robyn Boyle and Qinlei Huang and Hui Zhang and Anderson, {Vicki A.} and Amar Gajjar",

note = "Funding Information: National Cancer Institute through a Cancer Center Support (CORE) grant (P30-CA21765), the Noyes Brain Tumor Foundation, Musicians Against Childhood Cancer (MACC), and the American Lebanese Syrian Associated Charities (ALSAC).",

year = "2014",

month = jun,

doi = "10.1093/jpepsy/jsu009",

language = "English (US)",

volume = "39",

pages = "501--511",

journal = "Journal of pediatric psychology",

issn = "0146-8693",

publisher = "Oxford University Press",

number = "5",

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Knight, SJ, Conklin, HM, Palmer, SL, Schreiber, JE, Armstrong, CL, Wallace, D, Bonner, M, Swain, MA, Evankovich, KD, Mabbott, DJ, Boyle, R, Huang, Q, Zhang, H, Anderson, VA & Gajjar, A 2014, 'Working memory abilities among children treated for medulloblastoma: Parent report and child performance', Journal of pediatric psychology, vol. 39, no. 5, pp. 501-511. https://doi.org/10.1093/jpepsy/jsu009

TY - JOUR

T1 - Working memory abilities among children treated for medulloblastoma

T2 - Parent report and child performance

AU - Knight, Sarah J.

AU - Conklin, Heather M.

AU - Palmer, Shawna L.

AU - Schreiber, Jane E.

AU - Armstrong, Carol L.

AU - Wallace, Dana

AU - Bonner, Melanie

AU - Swain, Michelle A.

AU - Evankovich, Karen D.

AU - Mabbott, Donald J.

AU - Boyle, Robyn

AU - Huang, Qinlei

AU - Zhang, Hui

AU - Anderson, Vicki A.

AU - Gajjar, Amar

N1 - Funding Information: National Cancer Institute through a Cancer Center Support (CORE) grant (P30-CA21765), the Noyes Brain Tumor Foundation, Musicians Against Childhood Cancer (MACC), and the American Lebanese Syrian Associated Charities (ALSAC).

PY - 2014/6

Y1 - 2014/6

N2 - ObjectiveWe investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.MethodThis study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.Results There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only. ConclusionsMost children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.

AB - ObjectiveWe investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.MethodThis study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.Results There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only. ConclusionsMost children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.

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KW - cognitive assessment

KW - neurological disorders

KW - neuropsychology

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JF - Journal of pediatric psychology

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ER -

Working memory abilities among children treated for medulloblastoma: Parent report and child performance

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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