Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?

John M. Varlotto*, Malcom McAvoy DeCamp Jr, John C. Flickinger, Jessica Lake, Abram Recht, Chandra P. Belani, Michael F. Reed, Jennifer W. Toth, Heath B. Mackley, Christopher N. Sciamanna, Alan Lipton, Suhail M. Ali, Richkesvar P.M. Mahraj, Christopher R. Gilbert, Nengliang Yao

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The National Lung Screening Trial demonstrated that screening for lung cancer improved overall survival (OS) and reduced lung cancer mortality in the 55- to 74-year-old age group by increasing the proportion of cancers detected at an early stage. Because of the increasing life expectancy of the American population, we investigated whether screening for lung cancer might benefit men and women aged 75-84 years. Materials/Methods: Rates of non-small cell lung cancer (NSCLC) from 2000 to 2009 were calculated in both younger and older age groups using the surveillance epidemiology and end reporting database. OS and lung cancer-specific survival (LCSS) in patients with Stage I NSCLC diagnosed from 2004 to 2009 were analyzed to determine the effects of age and treatment. Results: The per capita incidence of NSCLC decreased in the 55-74 cohort, but increased in the 75-84 cohort over the study period. Crude lung cancer death rates in the two age groups who had no specific treatment were 39.5 and 44.9%, respectively. These rates fell in both age groups when increasingly aggressive treatment was used. Rates of OS and LCSS improved significantly with increasingly aggressive treatment in the 75-84 age group. The survival benefits of increasingly aggressive treatment in 75- to 84-year-old females did not differ from their counterparts in the younger cohort. Conclusion: Screening for lung cancer might be of benefit to individuals at increased risk of lung cancer in the 75-84 age group. The survival benefits of aggressive therapy are similar in females between 55-74 and 75-84 years old.

Original languageEnglish (US)
Article numberArticle 37
JournalFrontiers in Oncology
Volume4 MAR
DOIs
StatePublished - Jan 1 2014

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Lung Neoplasms
Age Groups
Survival
Non-Small Cell Lung Carcinoma
Therapeutics
Mortality
Life Expectancy
Epidemiology
Cohort Studies
Survival Rate
Databases
Lung
Incidence
Population
Neoplasms

Keywords

  • Elderly
  • Lung cancer
  • Radiotherapy
  • Screening
  • Thoracic surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Varlotto, J. M., DeCamp Jr, M. M., Flickinger, J. C., Lake, J., Recht, A., Belani, C. P., ... Yao, N. (2014). Would screening for lung cancer benefit 75- to 84-year-old residents of the United States? Frontiers in Oncology, 4 MAR, [Article 37]. https://doi.org/10.3389/fonc.2014.00037
Varlotto, John M. ; DeCamp Jr, Malcom McAvoy ; Flickinger, John C. ; Lake, Jessica ; Recht, Abram ; Belani, Chandra P. ; Reed, Michael F. ; Toth, Jennifer W. ; Mackley, Heath B. ; Sciamanna, Christopher N. ; Lipton, Alan ; Ali, Suhail M. ; Mahraj, Richkesvar P.M. ; Gilbert, Christopher R. ; Yao, Nengliang. / Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?. In: Frontiers in Oncology. 2014 ; Vol. 4 MAR.
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title = "Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?",
abstract = "Background: The National Lung Screening Trial demonstrated that screening for lung cancer improved overall survival (OS) and reduced lung cancer mortality in the 55- to 74-year-old age group by increasing the proportion of cancers detected at an early stage. Because of the increasing life expectancy of the American population, we investigated whether screening for lung cancer might benefit men and women aged 75-84 years. Materials/Methods: Rates of non-small cell lung cancer (NSCLC) from 2000 to 2009 were calculated in both younger and older age groups using the surveillance epidemiology and end reporting database. OS and lung cancer-specific survival (LCSS) in patients with Stage I NSCLC diagnosed from 2004 to 2009 were analyzed to determine the effects of age and treatment. Results: The per capita incidence of NSCLC decreased in the 55-74 cohort, but increased in the 75-84 cohort over the study period. Crude lung cancer death rates in the two age groups who had no specific treatment were 39.5 and 44.9{\%}, respectively. These rates fell in both age groups when increasingly aggressive treatment was used. Rates of OS and LCSS improved significantly with increasingly aggressive treatment in the 75-84 age group. The survival benefits of increasingly aggressive treatment in 75- to 84-year-old females did not differ from their counterparts in the younger cohort. Conclusion: Screening for lung cancer might be of benefit to individuals at increased risk of lung cancer in the 75-84 age group. The survival benefits of aggressive therapy are similar in females between 55-74 and 75-84 years old.",
keywords = "Elderly, Lung cancer, Radiotherapy, Screening, Thoracic surgery",
author = "Varlotto, {John M.} and {DeCamp Jr}, {Malcom McAvoy} and Flickinger, {John C.} and Jessica Lake and Abram Recht and Belani, {Chandra P.} and Reed, {Michael F.} and Toth, {Jennifer W.} and Mackley, {Heath B.} and Sciamanna, {Christopher N.} and Alan Lipton and Ali, {Suhail M.} and Mahraj, {Richkesvar P.M.} and Gilbert, {Christopher R.} and Nengliang Yao",
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Varlotto, JM, DeCamp Jr, MM, Flickinger, JC, Lake, J, Recht, A, Belani, CP, Reed, MF, Toth, JW, Mackley, HB, Sciamanna, CN, Lipton, A, Ali, SM, Mahraj, RPM, Gilbert, CR & Yao, N 2014, 'Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?', Frontiers in Oncology, vol. 4 MAR, Article 37. https://doi.org/10.3389/fonc.2014.00037

Would screening for lung cancer benefit 75- to 84-year-old residents of the United States? / Varlotto, John M.; DeCamp Jr, Malcom McAvoy; Flickinger, John C.; Lake, Jessica; Recht, Abram; Belani, Chandra P.; Reed, Michael F.; Toth, Jennifer W.; Mackley, Heath B.; Sciamanna, Christopher N.; Lipton, Alan; Ali, Suhail M.; Mahraj, Richkesvar P.M.; Gilbert, Christopher R.; Yao, Nengliang.

In: Frontiers in Oncology, Vol. 4 MAR, Article 37, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?

AU - Varlotto, John M.

AU - DeCamp Jr, Malcom McAvoy

AU - Flickinger, John C.

AU - Lake, Jessica

AU - Recht, Abram

AU - Belani, Chandra P.

AU - Reed, Michael F.

AU - Toth, Jennifer W.

AU - Mackley, Heath B.

AU - Sciamanna, Christopher N.

AU - Lipton, Alan

AU - Ali, Suhail M.

AU - Mahraj, Richkesvar P.M.

AU - Gilbert, Christopher R.

AU - Yao, Nengliang

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: The National Lung Screening Trial demonstrated that screening for lung cancer improved overall survival (OS) and reduced lung cancer mortality in the 55- to 74-year-old age group by increasing the proportion of cancers detected at an early stage. Because of the increasing life expectancy of the American population, we investigated whether screening for lung cancer might benefit men and women aged 75-84 years. Materials/Methods: Rates of non-small cell lung cancer (NSCLC) from 2000 to 2009 were calculated in both younger and older age groups using the surveillance epidemiology and end reporting database. OS and lung cancer-specific survival (LCSS) in patients with Stage I NSCLC diagnosed from 2004 to 2009 were analyzed to determine the effects of age and treatment. Results: The per capita incidence of NSCLC decreased in the 55-74 cohort, but increased in the 75-84 cohort over the study period. Crude lung cancer death rates in the two age groups who had no specific treatment were 39.5 and 44.9%, respectively. These rates fell in both age groups when increasingly aggressive treatment was used. Rates of OS and LCSS improved significantly with increasingly aggressive treatment in the 75-84 age group. The survival benefits of increasingly aggressive treatment in 75- to 84-year-old females did not differ from their counterparts in the younger cohort. Conclusion: Screening for lung cancer might be of benefit to individuals at increased risk of lung cancer in the 75-84 age group. The survival benefits of aggressive therapy are similar in females between 55-74 and 75-84 years old.

AB - Background: The National Lung Screening Trial demonstrated that screening for lung cancer improved overall survival (OS) and reduced lung cancer mortality in the 55- to 74-year-old age group by increasing the proportion of cancers detected at an early stage. Because of the increasing life expectancy of the American population, we investigated whether screening for lung cancer might benefit men and women aged 75-84 years. Materials/Methods: Rates of non-small cell lung cancer (NSCLC) from 2000 to 2009 were calculated in both younger and older age groups using the surveillance epidemiology and end reporting database. OS and lung cancer-specific survival (LCSS) in patients with Stage I NSCLC diagnosed from 2004 to 2009 were analyzed to determine the effects of age and treatment. Results: The per capita incidence of NSCLC decreased in the 55-74 cohort, but increased in the 75-84 cohort over the study period. Crude lung cancer death rates in the two age groups who had no specific treatment were 39.5 and 44.9%, respectively. These rates fell in both age groups when increasingly aggressive treatment was used. Rates of OS and LCSS improved significantly with increasingly aggressive treatment in the 75-84 age group. The survival benefits of increasingly aggressive treatment in 75- to 84-year-old females did not differ from their counterparts in the younger cohort. Conclusion: Screening for lung cancer might be of benefit to individuals at increased risk of lung cancer in the 75-84 age group. The survival benefits of aggressive therapy are similar in females between 55-74 and 75-84 years old.

KW - Elderly

KW - Lung cancer

KW - Radiotherapy

KW - Screening

KW - Thoracic surgery

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Varlotto JM, DeCamp Jr MM, Flickinger JC, Lake J, Recht A, Belani CP et al. Would screening for lung cancer benefit 75- to 84-year-old residents of the United States? Frontiers in Oncology. 2014 Jan 1;4 MAR. Article 37. https://doi.org/10.3389/fonc.2014.00037