X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

Joseph M. Kinsella, Rebecca E. Jimenez, Priya P. Karmali, Anthony M. Rush, V. Ramana Kotamraju, Nathan C. Gianneschi, Erkki Ruoslahti, Dwayne Stupack, Michael J. Sailor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles.

Original languageEnglish (US)
Pages (from-to)12308-12311
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number51
DOIs
StatePublished - Dec 16 2011

Keywords

  • cancer
  • imaging agents
  • nanomedicine
  • nanoparticles
  • peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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