X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

Joseph M. Kinsella; Rebecca E. Jimenez; Priya P. Karmali; Anthony M. Rush; V. Ramana Kotamraju; Nathan C. Gianneschi; Erkki Ruoslahti; Dwayne Stupack; Michael J. Sailor

doi:10.1002/anie.201104507

X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

Joseph M. Kinsella, Rebecca E. Jimenez, Priya P. Karmali, Anthony M. Rush, V. Ramana Kotamraju, Nathan C. Gianneschi, Erkki Ruoslahti, Dwayne Stupack, Michael J. Sailor^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

200 Scopus citations

Abstract

Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi ₂S ₃ nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles.

Original language	English (US)
Pages (from-to)	12308-12311
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	51
DOIs	https://doi.org/10.1002/anie.201104507
State	Published - Dec 16 2011

Funding

Keywords

cancer
imaging agents
nanomedicine
nanoparticles
peptides

ASJC Scopus subject areas

General Chemistry
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201104507

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title = "X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles",

abstract = "Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles.",

keywords = "cancer, imaging agents, nanomedicine, nanoparticles, peptides",

author = "Kinsella, {Joseph M.} and Jimenez, {Rebecca E.} and Karmali, {Priya P.} and Rush, {Anthony M.} and Kotamraju, {V. Ramana} and Gianneschi, {Nathan C.} and Erkki Ruoslahti and Dwayne Stupack and Sailor, {Michael J.}",

year = "2011",

month = dec,

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doi = "10.1002/anie.201104507",

language = "English (US)",

volume = "50",

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journal = "Angewandte Chemie - International Edition",

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T1 - X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

AU - Kinsella, Joseph M.

AU - Jimenez, Rebecca E.

AU - Karmali, Priya P.

AU - Rush, Anthony M.

AU - Kotamraju, V. Ramana

AU - Gianneschi, Nathan C.

AU - Ruoslahti, Erkki

AU - Stupack, Dwayne

AU - Sailor, Michael J.

PY - 2011/12/16

Y1 - 2011/12/16

N2 - Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles.

AB - Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles.

KW - cancer

KW - imaging agents

KW - nanomedicine

KW - nanoparticles

KW - peptides

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U2 - 10.1002/anie.201104507

DO - 10.1002/anie.201104507

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 51

ER -

X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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