X-ray zoom-in tomography of calcified tissue

Xianghui Xiao*, Francesco De Carlo, Stuart R Stock

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


X-ray computed tomography (XCT) is a powerful non-invasive imaging tool for biomedical applications. It provides not only morphology but also the absolute value of the linear attenuation coefficient distribution of the specimen in three dimensions, which is helpful in osteoporosis and other component-sensitive studies. Spatial resolution and specimen size are coupled through the detector's field of view (FOV) and the number of elements in the area detector. When the FOV is smaller than the specimen size, the truncated-data problem arises, which can cause large errors in the values of the volume elements (voxels) in the reconstruction. Zoom-in tomography is a technique that images a small region of interest (ROI) in a large-size specimen with high resolution and uses low-resolution data for the entire specimen to reduce reconstruction errors in the ROI. We developed a method to estimate the residual error in linear attenuation coefficient values persisting in zoom-in tomography and used it to judge the accuracy of zoom-in tomographic reconstructions. In this work, we imaged a sample of trabecular bone with zoom-in tomography and quantified differences in voxel values, concentrating on comparisons of low and high mineral regions of the bone.

Original languageEnglish (US)
Title of host publicationDevelopments in X-Ray Tomography VI
StatePublished - Nov 21 2008
EventDevelopments in X-Ray Tomography VI - San Diego, CA, United States
Duration: Aug 12 2008Aug 14 2008


OtherDevelopments in X-Ray Tomography VI
Country/TerritoryUnited States
CitySan Diego, CA


  • Bone
  • Medical imaging
  • Microtomography
  • Reconstruction errors
  • Zoom-in tomography

ASJC Scopus subject areas

  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Applied Mathematics
  • Condensed Matter Physics


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