Xenogeneic patch closure of the small intestine: A novel approach to fistula management

John R. Kirkpatrick*, W. D. Nguyen, D. H. Kim, T. L. Fitzgerald, H. S. Provido, H. B. Alam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Previous work from our laboratory demonstrated the feasibility of utilizing placental-derived collagen tissue matrix (CTM) as a bowel wall substitute. We reasoned that this technique would also be suitable in managing intestinal fistulae. To test this hypothesis, we created a chronic cecal fistula in rats and randomly managed some with primary repair and others with CTM replacement. Leak rates, mortality, bursting pressures and histologic scores were similar, suggesting that a chronic fistula can be successfully managed with either a CTM or primary repair. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalEuropean Surgical Research
Issue number2
StatePublished - 2000
Externally publishedYes


  • Anastomosis
  • Collagen matrix
  • Fistula
  • Tissue regeneration

ASJC Scopus subject areas

  • Surgery


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