Xenotropic virus and autoimmunity in NZB mice

Syamal K. Datta*, Robert S. Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The high‐grade expression of xenotropic virus in NZB mice is determined by two autosomal dominant loci (Nzv‐1 and Nzv‐2). The progeny of crosses between NZB and the “nonautoimmune” virus‐negative SWR strain segregate into three phenotypes: high‐virus, low‐virus, and virus‐negative. The virologic phenotypes of the animals could be dissociated from the presence of either autoantibodies or immune complex‐deposit nephritis and the latter could develop in the crosses without deposits of viral antigens in the glomeruli.

Original languageEnglish (US)
Pages (from-to)S113-S117
JournalArthritis & Rheumatism
Volume21
Issue number1 S
DOIs
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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