Xenotropic virus and autoimmunity in NZB mice

Syamal K. Datta; Robert S. Schwartz

doi:10.1002/art.1780210917

Xenotropic virus and autoimmunity in NZB mice

Syamal K. Datta^*, Robert S. Schwartz

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

Abstract

The high‐grade expression of xenotropic virus in NZB mice is determined by two autosomal dominant loci (Nzv‐1 and Nzv‐2). The progeny of crosses between NZB and the “nonautoimmune” virus‐negative SWR strain segregate into three phenotypes: high‐virus, low‐virus, and virus‐negative. The virologic phenotypes of the animals could be dissociated from the presence of either autoantibodies or immune complex‐deposit nephritis and the latter could develop in the crosses without deposits of viral antigens in the glomeruli.

Original language	English (US)
Pages (from-to)	S113-S117
Journal	Arthritis & Rheumatism
Volume	21
Issue number	1 S
DOIs	https://doi.org/10.1002/art.1780210917
State	Published - Jun 1978

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "The high‐grade expression of xenotropic virus in NZB mice is determined by two autosomal dominant loci (Nzv‐1 and Nzv‐2). The progeny of crosses between NZB and the “nonautoimmune” virus‐negative SWR strain segregate into three phenotypes: high‐virus, low‐virus, and virus‐negative. The virologic phenotypes of the animals could be dissociated from the presence of either autoantibodies or immune complex‐deposit nephritis and the latter could develop in the crosses without deposits of viral antigens in the glomeruli.",

author = "Datta, {Syamal K.} and Schwartz, {Robert S.}",

year = "1978",

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AU - Schwartz, Robert S.

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AB - The high‐grade expression of xenotropic virus in NZB mice is determined by two autosomal dominant loci (Nzv‐1 and Nzv‐2). The progeny of crosses between NZB and the “nonautoimmune” virus‐negative SWR strain segregate into three phenotypes: high‐virus, low‐virus, and virus‐negative. The virologic phenotypes of the animals could be dissociated from the presence of either autoantibodies or immune complex‐deposit nephritis and the latter could develop in the crosses without deposits of viral antigens in the glomeruli.

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Xenotropic virus and autoimmunity in NZB mice

Abstract

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