Y90 radioembolization of colorectal cancer liver metastases: Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance

Michael Vouche; Riad Salem; Frank H. Miller; Marc Lemort; Bruno Vanderlinden; Daniel De Becker; Alain Hendlisz; Patrick Flamen

doi:10.1016/j.clinimag.2014.12.016

Y90 radioembolization of colorectal cancer liver metastases: Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance

Michael Vouche^*, Riad Salem, Frank H. Miller, Marc Lemort, Bruno Vanderlinden, Daniel De Becker, Alain Hendlisz, Patrick Flamen

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization. Methods: Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2-3 months after Y90 radioembolization. Results: Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P< .001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P< .001) and metabolic active volume (P< .001) was observed. The change in these criteria was correlated with the change of SUVmax.

Original language	English (US)
Pages (from-to)	454-462
Number of pages	9
Journal	Clinical Imaging
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/j.clinimag.2014.12.016
State	Published - May 1 2015

Keywords

Colorectal cancer
Liver metastases
PET-CT
Radioembolization
Yttrium-90

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinimag.2014.12.016

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title = "Y90 radioembolization of colorectal cancer liver metastases: Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance",

abstract = "Purpose: To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization. Methods: Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2-3 months after Y90 radioembolization. Results: Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P< .001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P< .001) and metabolic active volume (P< .001) was observed. The change in these criteria was correlated with the change of SUVmax.",

keywords = "Colorectal cancer, Liver metastases, PET-CT, Radioembolization, Yttrium-90",

author = "Michael Vouche and Riad Salem and Miller, {Frank H.} and Marc Lemort and Bruno Vanderlinden and {De Becker}, Daniel and Alain Hendlisz and Patrick Flamen",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.clinimag.2014.12.016",

language = "English (US)",

volume = "39",

pages = "454--462",

journal = "Clinical Imaging",

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T1 - Y90 radioembolization of colorectal cancer liver metastases

T2 - Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance

AU - Vouche, Michael

AU - Salem, Riad

AU - Miller, Frank H.

AU - Lemort, Marc

AU - Vanderlinden, Bruno

AU - De Becker, Daniel

AU - Hendlisz, Alain

AU - Flamen, Patrick

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Purpose: To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization. Methods: Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2-3 months after Y90 radioembolization. Results: Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P< .001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P< .001) and metabolic active volume (P< .001) was observed. The change in these criteria was correlated with the change of SUVmax.

AB - Purpose: To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization. Methods: Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2-3 months after Y90 radioembolization. Results: Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P< .001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P< .001) and metabolic active volume (P< .001) was observed. The change in these criteria was correlated with the change of SUVmax.

KW - Colorectal cancer

KW - Liver metastases

KW - PET-CT

KW - Radioembolization

KW - Yttrium-90

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Y90 radioembolization of colorectal cancer liver metastases: Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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