Y90 radioembolization of colorectal cancer liver metastases: Response assessment by contrast-enhanced computed tomography with or without PET-CT guidance

Michael Vouche*, Riad Salem, Frank H. Miller, Marc Lemort, Bruno Vanderlinden, Daniel De Becker, Alain Hendlisz, Patrick Flamen

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose: To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization. Methods: Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2-3 months after Y90 radioembolization. Results: Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P< .001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P< .001) and metabolic active volume (P< .001) was observed. The change in these criteria was correlated with the change of SUVmax.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalClinical Imaging
Volume39
Issue number3
DOIs
StatePublished - May 1 2015

Keywords

  • Colorectal cancer
  • Liver metastases
  • PET-CT
  • Radioembolization
  • Yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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