Yardstick for the medical management of chronic rhinosinusitis

Larry Borish, Fuad M. Baroody, Margaret S. Kim, Jay A. Lieberman, Anju Peters, Whitney W. Stevens, Jonathan A. Bernstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Chronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses defined by classic symptoms, imaging findings, or endoscopic findings. There are a growing number of emerging pharmacologic therapies being evaluated to treat patients with CRS, some of which have gained indication status in the United States. There have not been updated treatment guidelines published in the United States however since 2014. This document is meant to serve as an updated expert consensus document for the pharmacologic management of patients with CRS. We review available data focusing on prospective clinical trials on oral and intranasal corticosteroids, nasal irrigation, biologics, antibiotics, and allergy immunotherapy for CRS both with and without nasal polyposis, including specific therapies for aspirin-exacerbated respiratory disease–associated CRS and allergic fungal CRS. There are multiple options to treat CRS, and clinicians should be knowledgeable on the efficacy and risks of these available therapies. Allergists-immunologists now have various therapies available to treat patients with CRS.

Original languageEnglish (US)
Pages (from-to)118-128
Number of pages11
JournalAnnals of Allergy, Asthma and Immunology
Issue number2
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Immunology


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