Youth Living with Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared with HIV-Exposed Uninfected Youth

the Pediatric HIV/AIDS Cohort Study (PHACS)

doi:10.1097/QAI.0000000000002622

Youth Living with Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared with HIV-Exposed Uninfected Youth

the Pediatric HIV/AIDS Cohort Study (PHACS)

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Few studies have evaluated physical activity patterns or their association with vascular inflammation among youth living with perinatally acquired HIV (YPHIV). Methods: We assessed YPHIV and youth perinatally HIV-exposed but uninfected (YPHEU) in the PHACS Adolescent Master Protocol with at least one Block physical activity questionnaire (PAQ) completed between ages 7–19 years. Physical activity metrics were as follows: (1) daily total energy expenditure (TEE) and (2) physical activity duration (PAD) defined as the minutes of daily moderate and vigorous activities. In a subgroup, we measured serum biomarkers of coagulation (fibrinogen and P-selectin) and endothelial dysfunction (soluble intracellular cell adhesion molecule-1, soluble vascular cell adhesion molecule-1, and E-selectin) obtained within 3 months of a single PAQ. Repeated measures linear regression models were used to compare the trajectories of log-transformed TEE and PAD by HIV status, adjusting for confounders. Spearman correlations were calculated to assess the relationship of TEE and PAD with vascular biomarkers. Results: Five hundred ninety-six youth (387 YPHIV and 209 YPHEU) completed 1552 PAQs (median PAQs completed = 3). The median age at enrollment (Q1, Q3) was 11 (9, 13) years. TEE and PAD increased with age in both YPHIV and YPHEU. However, even after adjusting for confounders, YPHIV had significantly less increase per year than YPHEU for TEE (5.7% [95% confidence interval (CI): 29.9% to 21.4%, P = 0.010] less) and PAD (5.2% [95% CI: 29.2% to 21.1%, P = 0.016] less). Among 302 youth with biomarker measures (187 YPHIV and 114 YPHEU), we observed little correlation with TEE or PAD. Conclusions: Both groups had increases in physical activity levels as they aged, but YPHIV had smaller increases throughout adolescence compared with YPHEU, which may impact long-term health.

Original language	English (US)
Pages (from-to)	700-705
Number of pages	6
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	87
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000002622
State	Published - May 1 2021

Funding

The authors thank the participants and families for their participation in PHACS and the individuals and institutions involved in the conduct of PHACS. The following institutions, clinical site investigators, and staff participated in conducting PHACS AMP and AMP Up in 2018, in alphabetical order: Ann & Robert H. Lurie Children’s Hospital of Chicago: Ellen Chadwick, Margaret Ann Sanders, Kathleen Malee, and Yoonsun Pyun; Baylor College of Medicine: William Shearer, Mary Paul, Chivon McMullen-Jackson, Mandi Speer, and Lynnette Harris; Bronx Lebanon Hospital Center: Murli Purswani, Mahboobullah Mirza Baig, and Alma Villegas; Children’s Diagnostic & Treatment Center: Lisa Gaye-Robinson, Sandra Navarro, and Patricia Garvie; Boston Children’s Hospital: Sandra K. Burchett, Michelle E. Anderson, and Adam R. Cassidy; Jacobi Medical Center: Andrew Wiznia, Marlene Burey, Ray Shaw, and Raphaelle Auguste; Rutgers New Jersey Medical School: Arry Dieudonne, Linda Bettica, Juliette Johnson, and Karen Surowiec; St. Christopher’s Hospital for Children: Janet S. Chen, Maria Garcia Bulkley, Taesha White, and Mitzie Grant; St. Jude Children’s Research Hospital: Katherine Knapp, Kim Allison, Megan Wilkins, and Jamie Russell-Bell; San Juan Hospital/Department of Pediatrics: Midnela Acevedo-Flores, Heida Rios, and Vivian Olivera; Tulane University School of Medicine: Margarita Silio, Medea Gabriel, and Patricia Sirois; University of California, San Diego: Stephen A. Spector, Megan Loughran, Veronica Figueroa, and Sharon Nichols; University of Colorado Denver Health Sciences Center: Elizabeth McFarland, Carrie Chambers, Emily Barr, and Mary Glidden; and University of Miami: Gwendolyn Scott, Grace Alvarez, Juan Caffroni, and Anai Cuadra. Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse; the National Institute of Allergy and Infectious Diseases; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute on Deafness and Other Communication Disorders; the National Institute of Dental and Craniofacial Research; the National Cancer Institute; the National Institute on Alcohol Abuse and Alcoholism; the Office of AIDS Research; and the National Heart, Lung, and Blood Institute through cooperative agreements with the Harvard T.H. Chan School of Public Health (HD052102) (Principal Investigator: George R Seage III; Program Director: Liz Salomon) and the Tulane University School of Medicine (HD052104) (Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Ellen Chadwick; Project Director: Patrick Davis). Data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (PI: Julie Davidson).

Keywords

cardiovascular
exercise
inflammation
pediatric

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/QAI.0000000000002622

Cite this

@article{5294a686a93f473ab1e1fa5f3bbce056,

title = "Youth Living with Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared with HIV-Exposed Uninfected Youth",

abstract = "Background: Few studies have evaluated physical activity patterns or their association with vascular inflammation among youth living with perinatally acquired HIV (YPHIV). Methods: We assessed YPHIV and youth perinatally HIV-exposed but uninfected (YPHEU) in the PHACS Adolescent Master Protocol with at least one Block physical activity questionnaire (PAQ) completed between ages 7–19 years. Physical activity metrics were as follows: (1) daily total energy expenditure (TEE) and (2) physical activity duration (PAD) defined as the minutes of daily moderate and vigorous activities. In a subgroup, we measured serum biomarkers of coagulation (fibrinogen and P-selectin) and endothelial dysfunction (soluble intracellular cell adhesion molecule-1, soluble vascular cell adhesion molecule-1, and E-selectin) obtained within 3 months of a single PAQ. Repeated measures linear regression models were used to compare the trajectories of log-transformed TEE and PAD by HIV status, adjusting for confounders. Spearman correlations were calculated to assess the relationship of TEE and PAD with vascular biomarkers. Results: Five hundred ninety-six youth (387 YPHIV and 209 YPHEU) completed 1552 PAQs (median PAQs completed = 3). The median age at enrollment (Q1, Q3) was 11 (9, 13) years. TEE and PAD increased with age in both YPHIV and YPHEU. However, even after adjusting for confounders, YPHIV had significantly less increase per year than YPHEU for TEE (5.7% [95% confidence interval (CI): 29.9% to 21.4%, P = 0.010] less) and PAD (5.2% [95% CI: 29.2% to 21.1%, P = 0.016] less). Among 302 youth with biomarker measures (187 YPHIV and 114 YPHEU), we observed little correlation with TEE or PAD. Conclusions: Both groups had increases in physical activity levels as they aged, but YPHIV had smaller increases throughout adolescence compared with YPHEU, which may impact long-term health.",

keywords = "cardiovascular, exercise, inflammation, pediatric",

author = "{the Pediatric HIV/AIDS Cohort Study (PHACS)} and Sahera Dirajlal-Fargo and Williams, {Paige L.} and Carly Broadwell and McFarland, {Elizabeth J.} and Powis, {Kathleen M.} and Jacobson, {Denise L.} and Jennifer Jao",

note = "Funding Information: The authors thank the participants and families for their participation in PHACS and the individuals and institutions involved in the conduct of PHACS. The following institutions, clinical site investigators, and staff participated in conducting PHACS AMP and AMP Up in 2018, in alphabetical order: Ann & Robert H. Lurie Children{\textquoteright}s Hospital of Chicago: Ellen Chadwick, Margaret Ann Sanders, Kathleen Malee, and Yoonsun Pyun; Baylor College of Medicine: William Shearer, Mary Paul, Chivon McMullen-Jackson, Mandi Speer, and Lynnette Harris; Bronx Lebanon Hospital Center: Murli Purswani, Mahboobullah Mirza Baig, and Alma Villegas; Children{\textquoteright}s Diagnostic & Treatment Center: Lisa Gaye-Robinson, Sandra Navarro, and Patricia Garvie; Boston Children{\textquoteright}s Hospital: Sandra K. Burchett, Michelle E. Anderson, and Adam R. Cassidy; Jacobi Medical Center: Andrew Wiznia, Marlene Burey, Ray Shaw, and Raphaelle Auguste; Rutgers New Jersey Medical School: Arry Dieudonne, Linda Bettica, Juliette Johnson, and Karen Surowiec; St. Christopher{\textquoteright}s Hospital for Children: Janet S. Chen, Maria Garcia Bulkley, Taesha White, and Mitzie Grant; St. Jude Children{\textquoteright}s Research Hospital: Katherine Knapp, Kim Allison, Megan Wilkins, and Jamie Russell-Bell; San Juan Hospital/Department of Pediatrics: Midnela Acevedo-Flores, Heida Rios, and Vivian Olivera; Tulane University School of Medicine: Margarita Silio, Medea Gabriel, and Patricia Sirois; University of California, San Diego: Stephen A. Spector, Megan Loughran, Veronica Figueroa, and Sharon Nichols; University of Colorado Denver Health Sciences Center: Elizabeth McFarland, Carrie Chambers, Emily Barr, and Mary Glidden; and University of Miami: Gwendolyn Scott, Grace Alvarez, Juan Caffroni, and Anai Cuadra. Funding Information: Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse; the National Institute of Allergy and Infectious Diseases; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute on Deafness and Other Communication Disorders; the National Institute of Dental and Craniofacial Research; the National Cancer Institute; the National Institute on Alcohol Abuse and Alcoholism; the Office of AIDS Research; and the National Heart, Lung, and Blood Institute through cooperative agreements with the Harvard T.H. Chan School of Public Health (HD052102) (Principal Investigator: George R Seage III; Program Director: Liz Salomon) and the Tulane University School of Medicine (HD052104) (Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Ellen Chadwick; Project Director: Patrick Davis). Data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (PI: Julie Davidson). Publisher Copyright: {\textcopyright} 2021 Wolters Kluwer Health, Inc. All rights reserved.",

year = "2021",

month = may,

day = "1",

doi = "10.1097/QAI.0000000000002622",

language = "English (US)",

volume = "87",

pages = "700--705",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

publisher = "Wolters Kluwer Health",

number = "1",

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TY - JOUR

T1 - Youth Living with Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared with HIV-Exposed Uninfected Youth

AU - the Pediatric HIV/AIDS Cohort Study (PHACS)

AU - Dirajlal-Fargo, Sahera

AU - Williams, Paige L.

AU - Broadwell, Carly

AU - McFarland, Elizabeth J.

AU - Powis, Kathleen M.

AU - Jacobson, Denise L.

AU - Jao, Jennifer

N1 - Funding Information: The authors thank the participants and families for their participation in PHACS and the individuals and institutions involved in the conduct of PHACS. The following institutions, clinical site investigators, and staff participated in conducting PHACS AMP and AMP Up in 2018, in alphabetical order: Ann & Robert H. Lurie Children’s Hospital of Chicago: Ellen Chadwick, Margaret Ann Sanders, Kathleen Malee, and Yoonsun Pyun; Baylor College of Medicine: William Shearer, Mary Paul, Chivon McMullen-Jackson, Mandi Speer, and Lynnette Harris; Bronx Lebanon Hospital Center: Murli Purswani, Mahboobullah Mirza Baig, and Alma Villegas; Children’s Diagnostic & Treatment Center: Lisa Gaye-Robinson, Sandra Navarro, and Patricia Garvie; Boston Children’s Hospital: Sandra K. Burchett, Michelle E. Anderson, and Adam R. Cassidy; Jacobi Medical Center: Andrew Wiznia, Marlene Burey, Ray Shaw, and Raphaelle Auguste; Rutgers New Jersey Medical School: Arry Dieudonne, Linda Bettica, Juliette Johnson, and Karen Surowiec; St. Christopher’s Hospital for Children: Janet S. Chen, Maria Garcia Bulkley, Taesha White, and Mitzie Grant; St. Jude Children’s Research Hospital: Katherine Knapp, Kim Allison, Megan Wilkins, and Jamie Russell-Bell; San Juan Hospital/Department of Pediatrics: Midnela Acevedo-Flores, Heida Rios, and Vivian Olivera; Tulane University School of Medicine: Margarita Silio, Medea Gabriel, and Patricia Sirois; University of California, San Diego: Stephen A. Spector, Megan Loughran, Veronica Figueroa, and Sharon Nichols; University of Colorado Denver Health Sciences Center: Elizabeth McFarland, Carrie Chambers, Emily Barr, and Mary Glidden; and University of Miami: Gwendolyn Scott, Grace Alvarez, Juan Caffroni, and Anai Cuadra. Funding Information: Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse; the National Institute of Allergy and Infectious Diseases; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute on Deafness and Other Communication Disorders; the National Institute of Dental and Craniofacial Research; the National Cancer Institute; the National Institute on Alcohol Abuse and Alcoholism; the Office of AIDS Research; and the National Heart, Lung, and Blood Institute through cooperative agreements with the Harvard T.H. Chan School of Public Health (HD052102) (Principal Investigator: George R Seage III; Program Director: Liz Salomon) and the Tulane University School of Medicine (HD052104) (Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Ellen Chadwick; Project Director: Patrick Davis). Data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (PI: Julie Davidson). Publisher Copyright: © 2021 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Background: Few studies have evaluated physical activity patterns or their association with vascular inflammation among youth living with perinatally acquired HIV (YPHIV). Methods: We assessed YPHIV and youth perinatally HIV-exposed but uninfected (YPHEU) in the PHACS Adolescent Master Protocol with at least one Block physical activity questionnaire (PAQ) completed between ages 7–19 years. Physical activity metrics were as follows: (1) daily total energy expenditure (TEE) and (2) physical activity duration (PAD) defined as the minutes of daily moderate and vigorous activities. In a subgroup, we measured serum biomarkers of coagulation (fibrinogen and P-selectin) and endothelial dysfunction (soluble intracellular cell adhesion molecule-1, soluble vascular cell adhesion molecule-1, and E-selectin) obtained within 3 months of a single PAQ. Repeated measures linear regression models were used to compare the trajectories of log-transformed TEE and PAD by HIV status, adjusting for confounders. Spearman correlations were calculated to assess the relationship of TEE and PAD with vascular biomarkers. Results: Five hundred ninety-six youth (387 YPHIV and 209 YPHEU) completed 1552 PAQs (median PAQs completed = 3). The median age at enrollment (Q1, Q3) was 11 (9, 13) years. TEE and PAD increased with age in both YPHIV and YPHEU. However, even after adjusting for confounders, YPHIV had significantly less increase per year than YPHEU for TEE (5.7% [95% confidence interval (CI): 29.9% to 21.4%, P = 0.010] less) and PAD (5.2% [95% CI: 29.2% to 21.1%, P = 0.016] less). Among 302 youth with biomarker measures (187 YPHIV and 114 YPHEU), we observed little correlation with TEE or PAD. Conclusions: Both groups had increases in physical activity levels as they aged, but YPHIV had smaller increases throughout adolescence compared with YPHEU, which may impact long-term health.

AB - Background: Few studies have evaluated physical activity patterns or their association with vascular inflammation among youth living with perinatally acquired HIV (YPHIV). Methods: We assessed YPHIV and youth perinatally HIV-exposed but uninfected (YPHEU) in the PHACS Adolescent Master Protocol with at least one Block physical activity questionnaire (PAQ) completed between ages 7–19 years. Physical activity metrics were as follows: (1) daily total energy expenditure (TEE) and (2) physical activity duration (PAD) defined as the minutes of daily moderate and vigorous activities. In a subgroup, we measured serum biomarkers of coagulation (fibrinogen and P-selectin) and endothelial dysfunction (soluble intracellular cell adhesion molecule-1, soluble vascular cell adhesion molecule-1, and E-selectin) obtained within 3 months of a single PAQ. Repeated measures linear regression models were used to compare the trajectories of log-transformed TEE and PAD by HIV status, adjusting for confounders. Spearman correlations were calculated to assess the relationship of TEE and PAD with vascular biomarkers. Results: Five hundred ninety-six youth (387 YPHIV and 209 YPHEU) completed 1552 PAQs (median PAQs completed = 3). The median age at enrollment (Q1, Q3) was 11 (9, 13) years. TEE and PAD increased with age in both YPHIV and YPHEU. However, even after adjusting for confounders, YPHIV had significantly less increase per year than YPHEU for TEE (5.7% [95% confidence interval (CI): 29.9% to 21.4%, P = 0.010] less) and PAD (5.2% [95% CI: 29.2% to 21.1%, P = 0.016] less). Among 302 youth with biomarker measures (187 YPHIV and 114 YPHEU), we observed little correlation with TEE or PAD. Conclusions: Both groups had increases in physical activity levels as they aged, but YPHIV had smaller increases throughout adolescence compared with YPHEU, which may impact long-term health.

KW - cardiovascular

KW - exercise

KW - inflammation

KW - pediatric

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U2 - 10.1097/QAI.0000000000002622

DO - 10.1097/QAI.0000000000002622

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AN - SCOPUS:85103994471

SN - 1525-4135

VL - 87

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JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 1

ER -

Youth Living with Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared with HIV-Exposed Uninfected Youth

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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