TY - JOUR
T1 - Yttrium-90 for colorectal liver metastasis - the promising role of radiation segmentectomy as an alternative local cure
AU - Entezari, Pouya
AU - Gabr, Ahmed
AU - Salem, Riad
AU - Lewandowski, Robert J.
N1 - Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - The majority of patients with metastatic colorectal cancer (CRC) to the liver are not amenable to curative-intent surgery or thermal ablation; there is a need for alternative locoregional therapies to control oligometastatic liver disease. Sequential lobar Yttrium-90 (Y90) radioembolization has demonstrated favorable results in the salvage setting for CRC patients with liver only or liver-dominant metastatic disease, but the role of Y90 in earlier-stage disease has not shown to be as promising. Recently, radiation segmentectomy, the super selective delivery of high (ablative) dose Y90 microspheres, has been introduced as a novel approach for patients with unresectable hepatocellular carcinoma. This review provides an overview of the current role of Y90 radioembolization for CRC patients with metastasis to the liver, with specific focus on the evolving application of radiation segmentectomy for patients with limited hepatic metastases from colorectal cancer.
AB - The majority of patients with metastatic colorectal cancer (CRC) to the liver are not amenable to curative-intent surgery or thermal ablation; there is a need for alternative locoregional therapies to control oligometastatic liver disease. Sequential lobar Yttrium-90 (Y90) radioembolization has demonstrated favorable results in the salvage setting for CRC patients with liver only or liver-dominant metastatic disease, but the role of Y90 in earlier-stage disease has not shown to be as promising. Recently, radiation segmentectomy, the super selective delivery of high (ablative) dose Y90 microspheres, has been introduced as a novel approach for patients with unresectable hepatocellular carcinoma. This review provides an overview of the current role of Y90 radioembolization for CRC patients with metastasis to the liver, with specific focus on the evolving application of radiation segmentectomy for patients with limited hepatic metastases from colorectal cancer.
KW - Colon cancer
KW - metastatic liver disease
KW - radiation segmentectomy
KW - radioembolization
KW - segmental radioembolization
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U2 - 10.1080/02656736.2021.1933215
DO - 10.1080/02656736.2021.1933215
M3 - Review article
C2 - 35465813
AN - SCOPUS:85128800755
SN - 0265-6736
VL - 39
SP - 620
EP - 626
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 1
ER -