Abstract
The purpose of this study was to define the optimal infusion parameters and operator radiation exposure for yttrium-90 (90Y) radioembolization in the VX2 rabbit model of liver cancer. Forty-one rabbits with VX2 were treated with glass microspheres with vial sizes of 1, 3, and 5 GBq. The mean administered activity was 51.5 MBq (95% CI, 39.1–63.9). Delivery efficiency improved with 1 GBq versus with 3 GBq (residual 11.0% vs 46.4%, respectively; P = .0013) and improved with 1 GBq versus with 5 GBq (residual 11.0% vs 33.8%, respectively; P = .0060). The mean operator extremity exposure was 41.7 μSv/infusion. The optimal minimum infusion volume and rate was 49 mL and 21 mL/min, respectively. Fecal elimination occurred with microsphere uptake in the gallbladder at 1 and 2 weeks. 90Y radioembolization can be safely and efficiently performed in the VX2 rabbit model. Methodological considerations as a “how-to” for the setup of a preclinical 90Y laboratory are included to support future translational research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1569-1574.e11 |
| Journal | Journal of Vascular and Interventional Radiology |
| Volume | 32 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2021 |
Funding
The authors thank Northwestern University Health Physics (Jose Macatangay, Donald Samaan, Joseph Princewill, Thomas E. Whittenhall Jr., Angelica Gheen) and Northwestern Memorial Hospital Department of Nuclear Medicine (Dr. Mike Zimmer, Scott M. Leonard, Peter Cutrera, Lisa Riehle, MacKenzie King, Antonella Guardioloa, Tory Maloy, Michelle Gruchot). Survival studies were supported through dedicated housing and accommodation by the Center for Comparative Medicine (Dr. Stephen I. Levin, Giovanni Pompilio). Imaging was made possible by Northwestern University’s Center for Translational Imaging (Dr. Daniel Procissi, Sol Misener). We are grateful for the generous funding provided by the SIR Foundation Allied Scientist Grant (A.C.G.) and the Department of Radiology of the Feinberg School of Medicine. A.C.G. was supported by the Medical Scientist Training Program ( T32GM008152 ). Dose vials, administration kits, and additional funding for research materials were provided through an Investigator Initiated Study (IIS) grant from BTG (Boston Scientific, Marlborough, Massachusetts). R.S. is supported in part by NIH grant CA126809 . R.J.L. is supported in part by NIH grant R01CA233878-01 . S.B.W. receives salary support from NIH grant 5R25 CA 132822-03 and the RSNA Foundation Research Scholar Grant. The listed authors performed data collection, analysis, and manuscript preparation independently without assistance from the funding sources. A.C.G. is a consultant for and reports personal fees from ABK, outside the submitted work. S.B.W. is a consultant for Guerbet, Cook, and NXT; reports personal fees from Guerbet, Cook, and NXT; and grants from Insightec, Siemen's, Guerbet, and FUSF, outside the submitted work. S.K.M. reports grants from Boston Scientific, outside the submitted work. R.A.O. was the founder of IO-RAD, which received grant funding from BTG. R.S. reports personal fees from Boston Scientific Corporation; Bard Peripheral Vascular, Inc.; Cook Medical; Eisai, Inc.; Exelixis, Inc.; Intellisphere, LLC; Dava Oncology, LP; and Dova Pharmaceuticals, outside the submitted work. R.J.L. reports personal fees from Boston Scientific, ABK Medical, and BD, outside the submitted work. None of the other authors have identified any conflict of interest.The authors thank Northwestern University Health Physics (Jose Macatangay, Donald Samaan, Joseph Princewill, Thomas E. Whittenhall Jr. Angelica Gheen) and Northwestern Memorial Hospital Department of Nuclear Medicine (Dr. Mike Zimmer, Scott M. Leonard, Peter Cutrera, Lisa Riehle, MacKenzie King, Antonella Guardioloa, Tory Maloy, Michelle Gruchot). Survival studies were supported through dedicated housing and accommodation by the Center for Comparative Medicine (Dr. Stephen I. Levin, Giovanni Pompilio). Imaging was made possible by Northwestern University's Center for Translational Imaging (Dr. Daniel Procissi, Sol Misener). We are grateful for the generous funding provided by the SIR Foundation Allied Scientist Grant (A.C.G.) and the Department of Radiology of the Feinberg School of Medicine. A.C.G. was supported by the Medical Scientist Training Program (T32GM008152). Dose vials, administration kits, and additional funding for research materials were provided through an Investigator Initiated Study (IIS) grant from BTG (Boston Scientific, Marlborough, Massachusetts). R.S. is supported in part by NIH grant CA126809. R.J.L. is supported in part by NIH grant R01CA233878-01. S.B.W. receives salary support from NIH grant 5R25 CA 132822-03 and the RSNA Foundation Research Scholar Grant. The listed authors performed data collection, analysis, and manuscript preparation independently without assistance from the funding sources.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
