Yttrium-90 radioembolization of hepatocellular carcinoma and metastatic disease to the liver

Robert J. Lewandowski, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Yttrium-90 (90Y) radioembolization is a catheter-based therapy that delivers internal radiation to hepatic tumors in the form of microspheres. 90Y can be delivered to the hepatic tumor as either a constituent of a glass microsphere, TheraSphere®, or as a biocompatible resin-based microsphere, SIR-Spheres®. Once embedded within the tumor microcirculation, these microspheres emit β-radiation at therapeutic levels. While the technical aspects of radioembolization are quite complex, the collective clinical experience presented in the literature supports the use of 90Y radioembolization for unresectable hepatic malignancies.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalSeminars in Interventional Radiology
Issue number1
StatePublished - Mar 2006


  • Hepatocellular carcinoma
  • Liver cancer
  • Liver tumor
  • Metastatic disease to the liver
  • Radioembolization
  • SIR-Sphere®
  • TheraSphere®
  • Yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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