Zebrafish: A Model System to Study the Architecture of Human Genetic Disease

Erica Ellen Davis*, Elias Nicholas Katsanis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The current ability to sequence whole exomes and genomes has reached an unprecedented pace. Variant data have been cataloged for >1 M individuals representative of Mendelian disease cohorts, complex trait consortia, and healthy populations. This flood of information, expected to grow hyperexponentially in the coming years, has already fuelled the development of animal models to assign physiological relevance of genotype to phenotype; to inform variant pathogenicity; and to dissect multilocus interactions. Here, we discuss zebrafish as a robust model system that offers similar genomic and anatomical orthology to humans, with the added advantages of experimental tractability and a refined set of molecular tools that enable scalable throughput analyses. We will compare and contrast zebrafish to other animal model systems; provide a historical perspective on zebrafish forward and reverse genetics; and we will overlay the relative strengths and weaknesses of the model to interpret pathomechanism of germline mutations in humans.

Original languageEnglish (US)
Title of host publicationAnimal Models for the Study of Human Disease
Subtitle of host publicationSecond Edition
PublisherElsevier Inc
Pages651-670
Number of pages20
ISBN (Electronic)9780124158948
ISBN (Print)9780128094686
DOIs
StatePublished - Jun 28 2017

Keywords

  • Disease mechanism
  • Genomics
  • Variant interpretation
  • Vertebrate model

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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