Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects

Keyphrases

• Antidepressants 100%
• N-methyl-D-aspartate Receptor (NMDAR) 100%
• Allosteric Modulator 100%
• Orally Bioavailable 100%
• Rodents 28%
• Long-term Potentiation 28%
• Synaptic Plasticity 28%
• Receptor Function 28%
• Phencyclidine 28%
• Hyperlocomotion 28%
• Therapeutic Development 14%
• Pharmacokinetics 14%
• N-methyl-D-aspartate Receptor Antagonist 14%
• Central Nervous System 14%
• Mouse Model 14%
• Cortical Neurons 14%
• Rodent Models 14%
• Major Depressive Disorder 14%
• Medial Prefrontal Cortex (mPFC) 14%
• Glutamatergic Receptors 14%
• Tolerability 14%
• Activity-dependent Plasticity 14%
• Receptor-mediated 14%
• Activity-dependent 14%
• Calcium Imaging 14%
• Rapid-acting Antidepressant 14%
• Cell Plasticity 14%
• Synaptic Transmission 14%
• Rat Brain 14%
• Oral Bioavailability 14%
• Oral Administration 14%
• Oral Dose 14%
• Functional Activity 14%
• Target Engagement 14%
• Single Oral Dose 14%
• Long-term Plasticity 14%
• Social Deficits 14%
• Forced Swim Test 14%
• Enhanced Activity 14%
• Depression Model 14%
• Rotarod Performance 14%
• Cerebrospinal Fluid Concentration 14%
• HEK Cells 14%
• Rotarod 14%
• B Subtype 14%

Neuroscience

• Antidepressant 100%
• NMDA Receptor 100%
• Receptor 75%
• Aspartic Acid 62%
• Synaptic Plasticity 50%
• Phencyclidine 25%
• Long-Term Potentiation 25%
• Central Nervous System 12%
• Major Depressive Disorder 12%
• Prefrontal Cortex 12%
• Calcium Imaging 12%
• In Vitro 12%
• NMDA Receptor Antagonist 12%
• Synaptic Transmission 12%
• Blood Plasma 12%
• Pharmacokinetics 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Antidepressant 100%
• Allosteric Modulator 100%
• N Methyl Dextro Aspartic Acid Receptor 100%
• Receptor 75%
• Aspartic Acid 62%
• Phencyclidine 25%
• Tolerability 12%
• Mouse Model 12%
• NMDA Receptor Antagonist 12%
• Major Depression 12%
• Bioavailability 12%
• Pharmacokinetics 12%