Zollinger-Ellison Syndrome with Multiple Endocrine Adenomatosis Type II

To the Editor: We report here an unusual association of Zollinger-Ellison syndrome with multiple endocrine adenomatosis Type II in a young man. This 28-year-old man was admitted to the Yale–New Haven Hospital because of epigastric pain. There was no recent history of vomiting, melena or salicylate abuse. He was a member of a local kindred with multiple endocrine adenomatosis Type II (Sipple's syndrome).¹ Five years before, medullary carcinoma of the thyroid was treated by total thyroidectomy; follow-up serum calcitonin levels and a liver biopsy revealed metastatic disease. One year previously, he had entered the Beth Israel Clinical Research Center for.