Zooming in on microscopic flow by remotely detected MRI

Vikram S. Bajaj, Jeffrey Paulsen, Elad Harel, Alexander Pines

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Magnetic resonance imaging (MRI) can elucidate the interior structure of an optically opaque object in unparalleled detail but is ultimately limited by the need to enclose the object within a detection coil; acquiring the image with increasingly smaller pixels reduces the sensitivity, because each pixel occupies a proportionately smaller fraction of the detector's volume. We developed a technique that overcomes this limitation by means of remotely detected MRI. Images of fluids flowing in channel assemblies are encoded into the phase and intensity of the constituent molecules' nuclear magnetic resonance signals and then decoded by a volume-matched detector after the fluids flow out of the sample. In combination with compressive sampling, we thus obtain microscopic images of flow and velocity distributions ∼106 times faster than is possible with conventional MRI on this hardware. Our results illustrate the facile integration of MRI with microfluidic assays and suggest generalizations to other systems involving microscopic flow.

Original languageEnglish (US)
Pages (from-to)1078-1081
Number of pages4
JournalScience
Volume330
Issue number6007
DOIs
StatePublished - Nov 19 2010

ASJC Scopus subject areas

  • General

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