ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: Is dynein the unifying theme?

Richard B. Vallee; Dileep Varma; Denis L. Dujardin

doi:10.4161/cc.5.21.3395

ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: Is dynein the unifying theme?

Richard B. Vallee^*, Dileep Varma, Denis L. Dujardin

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

Original language	English (US)
Pages (from-to)	2447-2451
Number of pages	5
Journal	Cell Cycle
Volume	5
Issue number	21
DOIs	https://doi.org/10.4161/cc.5.21.3395
State	Published - Nov 1 2006

Funding

We thank Brett Lauring, Janis Burkhardt, and Stephanie Stehman for helpful discussions. Supported by NIH Grant GM47434 to RBV and a Human Frontier Science Program fellowship to DLD.

Keywords

Checkpoint
Dynactin
Dynein
ER
Golgi
Mitosis
Targeting
Trafficking
Transport
Vesicle
ZW10

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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Cite this

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title = "ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: Is dynein the unifying theme?",

abstract = "ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.",

keywords = "Checkpoint, Dynactin, Dynein, ER, Golgi, Mitosis, Targeting, Trafficking, Transport, Vesicle, ZW10",

author = "Vallee, {Richard B.} and Dileep Varma and Dujardin, {Denis L.}",

note = "Funding Information: We thank Brett Lauring, Janis Burkhardt, and Stephanie Stehman for helpful discussions. Supported by NIH Grant GM47434 to RBV and a Human Frontier Science Program fellowship to DLD.",

year = "2006",

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doi = "10.4161/cc.5.21.3395",

language = "English (US)",

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T2 - Is dynein the unifying theme?

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AU - Varma, Dileep

AU - Dujardin, Denis L.

N1 - Funding Information: We thank Brett Lauring, Janis Burkhardt, and Stephanie Stehman for helpful discussions. Supported by NIH Grant GM47434 to RBV and a Human Frontier Science Program fellowship to DLD.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

AB - ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

KW - Checkpoint

KW - Dynactin

KW - Dynein

KW - ER

KW - Golgi

KW - Mitosis

KW - Targeting

KW - Trafficking

KW - Transport

KW - Vesicle

KW - ZW10

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ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: Is dynein the unifying theme?

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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