ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: Is dynein the unifying theme?

Richard B. Vallee*, Dileep Varma, Denis L. Dujardin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

Original languageEnglish (US)
Pages (from-to)2447-2451
Number of pages5
JournalCell Cycle
Volume5
Issue number21
DOIs
StatePublished - Nov 1 2006

Keywords

  • Checkpoint
  • Dynactin
  • Dynein
  • ER
  • Golgi
  • Mitosis
  • Targeting
  • Trafficking
  • Transport
  • Vesicle
  • ZW10

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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