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• Foreword

  Kelleher, N. L., Dec 1 2011, Protein and Peptide Analysis by LC-MS. Letzel, T. (ed.). (RSC Chromatography Monographs).

  Research output: Chapter in Book/Report/Conference proceeding › Foreword/postscript

• Top down proteomics

  Yates, J. R. & Kelleher, N. L., Jul 2 2013, In: Analytical Chemistry. 85, 13, p. 6151 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  27 Scopus citations

• Status of mass spectrometry-based proteomics and metabolomics in basic and translational research

  Kelleher, N. L., Jun 4 2013, In: Biochemistry. 52, 22, p. 3794-3796 3 p.

  Research output: Contribution to journal › Review article › peer-review
  4 Scopus citations

• Top-down proteomics

  Kelleher, N. L., Jul 12 2004, In: Analytical Chemistry. 76, 11, p. 196 A-203 A

  Research output: Contribution to journal › Review article › peer-review
  463 Scopus citations

• Illuminating the dark matter of shotgun proteomics

  Skinner, O. S. & Kelleher, N. L., Jul 8 2015, In: Nature Biotechnology. 33, 7, p. 717-718 2 p.

  Research output: Contribution to journal › Short survey › peer-review
  34 Scopus citations

• Top ten innovations 2010

  Jonathan, R., Caudy, A. M. Y. A., Kelleher, N. L. & Steven, H. W., Dec 1 2010, In: Scientist. 24, 12

  Research output: Contribution to journal › Article › peer-review

• Spinning up mass spectrometry for whole protein complexes

  Compton, P. D. & Kelleher, N. L., Nov 1 2012, In: Nature Methods. 9, 11, p. 1065-1066 2 p.

  Research output: Contribution to journal › Review article › peer-review
  11 Scopus citations

• 25^th ASMS Sanibel conference on top down mass spectrometry

  Kelleher, N. L. & Paša-Tolić, L., Jul 2013, In: Journal of the American Society for Mass Spectrometry. 24, 7, p. 983-985 3 p.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• Focus in Honor of Roman Zubarev, Recipient of the 2007 Biemann Medal

  Brodbelt, J. S., McLafferty, F. W. & Kelleher, N. L., Jun 2008, In: Journal of the American Society for Mass Spectrometry. 19, 6, p. 751-752 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  1 Scopus citations

• Electron Capture Dissociations Produces Many More Protein Backbone Cleavages Than Collisional and IR Excitation

  Zubarev, R. A., Fridriksson, E. K., Horn, D. M., Kelleher, N. L., Kruger, N. A., Lewis, M. A., Carpenter, B. K. & McLafferty, F. W., 1999, Mass Spectrometry in Biology and Medicine. Burlingame, A. L., Carr, S. A. & Baldwin, M. A. (eds.). p. 111-120

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Should LC-MS/MS Be the Reference Measurement Procedure to Determine Protein Concentrations in Human Samples?

  Hoofnagle, A. N., Cobbaert, C. M., Delatour, V., Kelleher, N. L., Lowenthal, M. S. & Shuford, C. M., Mar 1 2021, In: Clinical chemistry. 67, 3, p. 466-471 6 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  11 Scopus citations

• Erratum: Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization (Chemistry and Biology (1999) 6 (385-400))

  Shaw-Reid, C. A., Kelleher, N. L., Losey, H. C., Gehring, A. M., Berg, C. & Walsh, C. T., 1999, In: Chemistry and Biology. 6, 10, p. R290

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Proteoforms as the next proteomics currency: Identifying precise molecular forms of proteins can improve our understanding of function

  Smith, L. M. & Kelleher, N. L., Mar 9 2018, In: Science. 359, 6380, p. 1106-1107 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  206 Scopus citations

• To cyclize or not to cyclize: Catching enzyme evolution in the act

  Evans, B. S. & Kelleher, N. L., Jul 17 2009, In: ACS chemical biology. 4, 7, p. 495-497 3 p.

  Research output: Contribution to journal › Short survey › peer-review
  1 Scopus citations

• Ion mobility separation of variant histone tails extending to the "middle-down" range

  Shvartsburg, A. A., Zheng, Y., Smith, R. D. & Kelleher, N. L., May 15 2012, In: Analytical Chemistry. 84, 10, p. 4271-4276 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  37 Scopus citations

• Decoding protein modifications using top-down mass spectrometry

  Siuti, N. & Kelleher, N. L., Oct 2007, In: Nature Methods. 4, 10, p. 817-821 5 p.

  Research output: Contribution to journal › Article › peer-review
  417 Scopus citations

• Top-down proteomics: Where we are, where we are going?

  Fornelli, L., Toby, T. K., Schachner, L. F., Doubleday, P. F., Srzentić, K., DeHart, C. J. & Kelleher, N. L., Mar 20 2018, In: Journal of Proteomics. 175, p. 3-4 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  49 Scopus citations

• Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs

  Park, S., Ntai, I., Thomas, P., Konishcheva, E., Kelleher, N. L. & Statsuk, A. V., Oct 23 2012, In: Biochemistry. 51, 42, p. 8327-8329 3 p.

  Research output: Contribution to journal › Article › peer-review
  6 Scopus citations

• Deep and quantitative top-down proteomics in clinical and translational research

  Kelleher, N. L., Thomas, P. M., Ntai, I., Compton, P. D. & Leduc, R. D., Dec 1 2014, In: Expert Review of Proteomics. 11, 6, p. 649-651 3 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  33 Scopus citations

• Characterization of the mycoplasma pneumoniae proteome with 100% sequence coverage by high resolution MS/MS

  Miller, L. M., Du, Y., Johnson, J. R., Meng, F., Taylor, G. K. & Kelleher, N. L., Dec 1 2002, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. p. 167-168 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Attomole-Sensitivity Electrospray Source for Large-Molecule Mass Spectrometry

  Valaskovic, G. A., Kelleher, N. L., Little, D. P., Aaserud, D. J. & McLafferty, F. W., 1995, In: Analytical Chemistry. 67, 20, p. 3802-3805 4 p.

  Research output: Contribution to journal › Article › peer-review
  210 Scopus citations

• Processing complex mixtures of yeast proteins for direct fragmentation in a quadrupole-FTMS hybrid

  Meng, F., Cargile, B. J., Patrie, S. M., Johnson, J. R., Corso, T. N., Mcloughlin, S. M. & Kelleher, N. L., Dec 1 2002, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. p. 49-50 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Mass spectrometric characterization of human histone H3: A bird's eye view

  Thomas, C. E., Kelleher, N. L. & Mizzen, C. A., Feb 2006, In: Journal of Proteome Research. 5, 2, p. 240-247 8 p.

  Research output: Contribution to journal › Article › peer-review
  171 Scopus citations

• From primary structure to function: Biological insights from large-molecule mass spectra

  Kelleher, N. L., Feb 1 2000, In: Chemistry and Biology. 7, 2, p. R37-R45

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  28 Scopus citations

• Electron capture dissociation for robust production of sequence tags from eukaryotic proteins

  Kelleher, N. L., Patrie, S., Johnson, J. R., Meng, F. & Forbes, A. J., Dec 1 2002, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. p. 101-102 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Screening for expressed nonribosomal peptide synthetases and polyketide synthases using LC-MS/MS-based proteomics

  Chen, Y., McClure, R. A. & Kelleher, N. L., Feb 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 135-147 13 p. (Methods in Molecular Biology; vol. 1401).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  Open Access
  5 Scopus citations

• A cell-based approach to the human proteome project

  Kelleher, N. L., Oct 2012, In: Journal of the American Society for Mass Spectrometry. 23, 10, p. 1617-1624 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  46 Scopus citations

• Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

  Zha, L., Jiang, Y., Henke, M. T., Wilson, M. R., Wang, J. X., Kelleher, N. L. & Balskus, E. P., Oct 1 2017, In: Nature Chemical Biology. 13, 10, p. 1063-1065 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  43 Scopus citations

• Overexpression of recombinant proteins with a C-terminal thiocarboxylate: Implications for protein semisynthesis and thiamin biosynthesis

  Kinsland, C., Taylor, S. V., Kelleher, N. L., McLafferty, F. W. & Begley, T. P., 1998, In: Protein Science. 7, 8, p. 1839-1842 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  44 Scopus citations

• Separation of variant methylated histone tails by differential ion mobility

  Shvartsburg, A. A., Zheng, Y., Smith, R. D. & Kelleher, N. L., Aug 7 2012, In: Analytical Chemistry. 84, 15, p. 6317-6320 4 p.

  Research output: Contribution to journal › Article › peer-review
  48 Scopus citations

• Localization of labile posttranslational modifications by electron capture dissociation: The case of γ-carboxyglutamic acid

  Kelleher, N. L., Zubarev, R. A., Bush, K., Furie, B., Furie, B. C., McLafferty, F. W. & Walsh, C. T., Oct 1 1999, In: Analytical Chemistry. 71, 19, p. 4250-4253 4 p.

  Research output: Contribution to journal › Article › peer-review
  335 Scopus citations

• Epiproteomics: Quantitative analysis of histone marks and codes by mass spectrometry

  Zheng, Y., Huang, X. & Kelleher, N. L., Aug 1 2016, In: Current Opinion in Chemical Biology. 33, p. 142-150 9 p.

  Research output: Contribution to journal › Review article › peer-review
  62 Scopus citations

• Electron capture dissociation of multiply charged protein cations. A nonergodic process

  Zubarev, R. A., Kelleher, N. L. & McLafferty, F. W., Apr 8 1998, In: Journal of the American Chemical Society. 120, 13, p. 3265-3266 2 p.

  Research output: Contribution to journal › Letter › peer-review
  1711 Scopus citations

• Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo

  Evans, B. S., Robinson, S. J. & Kelleher, N. L., Jan 2011, In: Fungal Genetics and Biology. 48, 1, p. 49-61 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  48 Scopus citations

• Progress in Top-Down Proteomics and the Analysis of Proteoforms

  Toby, T. K., Fornelli, L. & Kelleher, N. L., Jun 12 2016, In: Annual Review of Analytical Chemistry. 9, p. 499-519 21 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  435 Scopus citations

• Bioinformatics analysis of top-down mass spectrometry data with proSight lite

  Dehart, C. J., Fellers, R. T., Fornelli, L., Kelleher, N. L. & Thomas, P. M., 2017, Methods in Molecular Biology. Humana Press Inc., p. 381-394 14 p. (Methods in Molecular Biology; vol. 1558).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  Open Access
  27 Scopus citations

• Attomole protein characterization by capillary electrophoresis-mass spectrometry

  Valaskovic, G. A., Kelleher, N. L. & McLafferty, F. W., 1996, In: Science. 273, 5279, p. 1199-1202 4 p.

  Research output: Contribution to journal › Article › peer-review
  354 Scopus citations

• ProSight Lite: Graphical software to analyze top-down mass spectrometry data

  Fellers, R. T., Greer, J. B., Early, B. P., Yu, X., Leduc, R. D., Kelleher, N. L. & Thomas, P. M., Apr 1 2015, In: Proteomics. 15, 7, p. 1235-1238 4 p.

  Research output: Contribution to journal › Article › peer-review
  195 Scopus citations

• Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

  Montaser, R. & Kelleher, N. L., May 15 2020, In: ACS chemical biology. 15, 5, p. 1134-1140 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Scopus citations

• In vitro characterization of a heterologously expressed nonribosomal peptide synthetase involved in phosphinothricin tripeptide biosynthesis

  Lee, J. H., Evans, B. S., Li, G., Kelleher, N. L. & Van Der Donk, W. A., Jun 16 2009, In: Biochemistry. 48, 23, p. 5054-5056 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  15 Scopus citations

• Evaluation of electron capture dissociation for D atom localization at the peptide and protein levels after solution phase exchange

  Charlebois, J. P., Patrie, S. M. & Kelleher, N. L., Dec 1 2002, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. p. 387-388 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Regioselectivity and chemoselectivity analysis of oxazole and thiazole ring formation by the peptide-heterocyclizing microcin B17 synthetase using high-resolution MS/MS [19]

  Kelleher, N. L., Belshaw, P. J. & Walsh, C. T., Sep 23 1998, In: Journal of the American Chemical Society. 120, 37, p. 9716-9717 2 p.

  Research output: Contribution to journal › Letter › peer-review
  26 Scopus citations

• Gene-specific characterization of human histone H2B by electron capture dissociation

  Siuti, N., Roth, M. J., Mizzen, C. A., Kelleher, N. L. & Pesavento, J. J., Feb 2006, In: Journal of Proteome Research. 5, 2, p. 233-239 7 p.

  Research output: Contribution to journal › Article › peer-review
  96 Scopus citations

• Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry

  McGee, J. P., Melani, R. D., Yip, P. F., Senko, M. W., Compton, P. D., Kafader, J. O. & Kelleher, N. L., Feb 9 2021, In: Analytical Chemistry. 93, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access
  35 Scopus citations

• Complete large-molecule high-resolution mass spectra from 50-femtomole microvolume injection

  Kelleher, N. L., Senko, M. W., Little, D. P., O'Connor, P. B. & McLafferty, F. W., 1995, In: Journal of the American Society for Mass Spectrometry. 6, 3, p. 220-221 2 p.

  Research output: Contribution to journal › Article › peer-review
  21 Scopus citations

• Top down proteomics of human membrane proteins from enriched mitochondrial fractions

  Catherman, A. D., Li, M., Tran, J. C., Durbin, K. R., Compton, P. D., Early, B. P., Thomas, P. M. & Kelleher, N. L., Feb 5 2013, In: Analytical Chemistry. 85, 3, p. 1880-1888 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  66 Scopus citations

• Electron capture dissociation and ¹³C,¹⁵N depletion for deuterium localization in intact proteins after solution-phase exchange

  Charlebois, J. P., Patrie, S. M. & Kelleher, N. L., Jul 1 2003, In: Analytical Chemistry. 75, 13, p. 3263-3266 4 p.

  Research output: Contribution to journal › Article › peer-review
  32 Scopus citations

• A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway

  Hollenhorst, M. A., Ntai, I., Badet, B., Kelleher, N. L. & Walsh, C. T., May 17 2011, In: Biochemistry. 50, 19, p. 3859-3861 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Scopus citations

• Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval

  Boyne, M. T., Garcia, B. A., Li, M., Zamdborg, L., Wenger, C. D., Babai, S. & Kelleher, N. L., Jan 2009, In: Journal of Proteome Research. 8, 1, p. 374-379 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  57 Scopus citations

• Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS

  Siuti, N. & Kelleher, N. L., Jan 15 2010, In: Analytical Biochemistry. 396, 2, p. 180-187 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Scopus citations