Content type
Experts
Search results
-
Richard B Silverman
- Chemistry - Professor, Patrick G. Ryan/Aon Professor
- Molecular Biosciences - Professor
- Pharmacology - Professor
- Chemistry PhD Program
- Interdisciplinary Biological Sciences PhD Program
- Northwestern University Interdepartmental Neuroscience PhD Program (NUIN)
- CLP - Chemistry of Life Processes Institute - Member
- IIN - International Institute for Nanotechnology - Member
- PCE - Proteomics Center of Excellence - Member
- Robert H. Lurie Comprehensive Cancer Center - Member
Person: Academic
-
Jay Z Yeh
- Pharmacology - Professor Emeritus
- Northwestern University Interdepartmental Neuroscience PhD Program (NUIN)
Person: Academic
-
-
-
Research Output
Search results
-
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis
Weerawarna, P. M., Schiefer, I. T., Soares, P., Fox, S., Morimoto, R. I., Melani, R. D., Kelleher, N. L., Luan, C. H. & Silverman, R. B., Jan 24 2024, In: ACS Central Science. 10, 1, p. 87-103 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
Genç, B., Gautam, M., Helmold, B. R., Koçak, N., Günay, A., Goshu, G. M., Silverman, R. B. & Hande Ozdinler, P., Dec 2022, In: Scientific reports. 12, 1, 5383.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology
Genç, B., Gautam, M., Gözütok, Ö., Dervishi, I., Sanchez, S., Goshu, G. M., Koçak, N., Xie, E., Silverman, R. B. & Özdinler, P. H., Feb 1 2021, In: Clinical and Translational Medicine. 11, 2Research output: Contribution to journal › Article › peer-review
Open Access -
The impact of the approval of riluzole
Sufit, R. & Newman, D., 1996, In: Neurology. 47, 4 SUPPL., p. S117Research output: Contribution to journal › Short survey › peer-review
1 Scopus citations -
Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels
Song, J. H., Huang, C. S., Nagata, K., Yeh, J. Z. & Narahashi, T., Aug 1997, In: Journal of Pharmacology and Experimental Therapeutics. 282, 2, p. 707-714 8 p.Research output: Contribution to journal › Article › peer-review
163 Scopus citations -
Stage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study
Pooled Resource Open-Access Als Clinical Trials Consortium, Jan 2 2020, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 21, 1-2, p. 140-143 4 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations
Grants
Search results
-
Investigations of the protein aggregation inhibitor NU-9 and its derivatives: mode of action and impact on Alzheimer’s disease and related dementias
Klein, W. L. (PD/PI), Ozdinler, H. (PD/PI) & Silverman, R. B. (PD/PI)
9/30/24 → 7/31/29
Project: Research project
-
Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, H. (PD/PI), Ozdinler, H. (PD/PI), Ozdinler, H. (PD/PI) & Silverman, R. B. (PD/PI)
8/1/19 → 9/29/24
Project: Research project
-
Silverman Subproject for Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Silverman, R. B. (PD/PI), Silverman, R. B. (PD/PI) & Silverman, R. B. (PD/PI)
8/1/19 → 9/29/24
Project: Research project
-
Protein Aggregation Inhibitors for ALS Therapy
Silverman, R. B. (PD/PI) & Morimoto, R. I. (Co-PD/PI)
U.S. Army Medical Research and Materiel Command
7/1/10 → 6/30/13
Project: Research project
-
Prot#AB19001: A Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Parallel Groups, Phase 3 Study to Compare the Efficacy and Safety of Masitinib in Combination with Riluzole Versus Placebo in Combination with Riluzole in the Treatmen
Ajroud-Driss, S. (PD/PI)
2/26/21 → 12/31/24
Project: Research project
-
Selective Inhibition of Neuronal Nitric Oxide Synthase
Silverman, R. B. (PD/PI)
National Institute of General Medical Sciences
3/1/11 → 8/31/15
Project: Research project
Research Data
Search results
-
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-2,5-difluorophenethyl)-4-methylpyridin-2-amine
Do, H. T. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Mar 13 2019
DOI: 10.2210/pdb6NGU/pdb, https://www.wwpdb.org/pdb?id=pdb_00006ngu
Dataset
-
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-Methyl-7-[3-((methylamino)methyl)phenethyl]quinolin-2-amine
Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), May 3 2017
DOI: 10.2210/pdb5UNV/pdb, https://www.wwpdb.org/pdb?id=pdb_00005unv
Dataset
-
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(3-(dimethylamino)propyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine
Do, H. T. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Mar 13 2019
DOI: 10.2210/pdb6NGS/pdb, https://www.wwpdb.org/pdb?id=pdb_00006ngs
Dataset
-
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(4-(dimethylamino)butyl)-4-methylpyridin-2-amine
Vasu, D. (Contributor), Li, H. (Contributor), Hardy, C. D. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Jul 13 2022
DOI: 10.2210/pdb7US8/pdb, https://www.wwpdb.org/pdb?id=pdb_00007us8
Dataset
-
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-methyl-6-(3-(methylamino)propyl)pyridin-2-amine
Vasu, D. (Contributor), Li, H. (Contributor), Hardy, C. D. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Jul 13 2022
DOI: 10.2210/pdb7TS7/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ts7
Dataset
-
Structure of human endothelial nitric oxide synthase heme domain in complex with (6-(3-(4,4-difluoropiperidin-1-yl)propyl)-4-methylpyridin-2-amine)
Vasu, D. (Contributor), Li, H. (Contributor), Hardy, C. D. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Jul 13 2022
DOI: 10.2210/pdb7UAO/pdb, https://www.wwpdb.org/pdb?id=pdb_00007uao
Dataset